A first-takes-all model of centriole copy number control based on cartwheel elongation.

ABSTRACT: How cells control the numbers of subcellular components is a fundamental question in biology. Given that biosynthetic processes are fundamentally stochastic it is utterly puzzling that some structures display no copy number variation within a cell population. Centriole biogenesis, with each centriole being duplicated once and only once per cell cycle, stands out due to its remarkable fidelity. This is a highly controlled process, which depends on low-abundance rate-limiting factors. How can exactly one centriole copy be produced given the variation in the concentration of these key factors? Hitherto, tentative explanations of this control evoked lateral inhibition- or phase separation-like mechanisms emerging from the dynamics of these rate-limiting factors but how strict centriole number

SUBMITTER: Dias Louro MA 

PROVIDER: S-EPMC8136855 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature