Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder.

ABSTRACT: Adaptive behavior requires balancing approach and avoidance based on the rewarding and aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a novel application of the drift diffusion model (DDM) suited to quantify how offers of reward and aversiveness, and neural correlates thereof, are dynamically integrated to form decisions, and how such processes are altered in MDD. Hierarchical parameter estimation from the DDM demonstrated that the MDD group differed in three distinct reward-related parameters driving approach-based decision making. First, MDD was associated with reduced reward sensitivity, measured as the impact of offered reward on evidence accumulation. Notably, this effect wa

SUBMITTER: Pedersen ML 

PROVIDER: S-EPMC8136861 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature