The effect of equine bone marrow-derived mesenchymal stem cells on the expression of apoptotic genes in neutrophils.

ABSTRACT:

Background

Bone marrow mesenchymal stem cells (BM-MSCs), as multipotent cells with self-renewal and plastic-adherent properties, have immunomodulatory effects on immune cells, including neutrophils. These cells are in close proximity in bone marrow (BM) sinusoids with non-multiplicative immature neutrophils. BM-MSCs exert their immunomodulatory effects on adjacent cells both directly (cell-to-cell contact) and indirectly (secretion of soluble factors).

Objectives

The aim of this study was to evaluate the effect of equine bone marrow mesenchymal stem cells (BM-MSCs) on the expression of some pro- and anti-apoptotic genes (p53, survivin and Bcl₂ ) in neutrophils co-cultured with BM-MSCs.

Methods

For this purpose, peripheral blood neutrophils were isolated and

SUBMITTER: Salami F 

PROVIDER: S-EPMC8136922 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature