Polymorphisms of KLF3 gene coding region and identification of their functionality for abdominal fat in chickens.

ABSTRACT: KLF3 is a member of the Kruppel-like factor (KLF) family of transcription factors, and plays an important role in several biological processes, including adipogenesis, erythropoiesis and B-cell development. The purposes of this study are to search for polymorphisms of KLF3 coding region and to provide functional evidence for abdominal fat in chickens. A total of 168 SNPs in KLF3 coding region were detected in a unique chicken population, the Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF). Of which three single nucleotide polymorphisms (g.3452T > C, g.8663A > G and g.10751G > A) were significantly correlated with abdominal fat weight (AFW) and abdominal fat percentage (AFP) of 329 birds from the 19th generation of NEAUHLF (FDR < 0.05

SUBMITTER: Wang W 

PROVIDER: S-EPMC8136968 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature