Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.

ABSTRACT: Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205⁺/CD172a⁺ conventional dendritic

SUBMITTER: Serrano-Lopez J 

PROVIDER: S-EPMC8137144 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature