Standardized and reproducible measurement of decision-making in mice.

ABSTRACT: Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements of mouse behavior. Here, we show that a standardized task to probe decision-making in mice produces reproducible results across multiple laboratories. We adopted a task for head-fixed mice that assays perceptual and value-based decision making, and we standardized training protocol and experimental hardware, software, and procedures. We trained 140 mice across seven laboratories in three countries, and we collected 5 million mouse choices into a publicly available database. Learning speed was variable across mice and laboratories, but once training was complete there we

SUBMITTER: International Brain Laboratory 

PROVIDER: S-EPMC8137147 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature