Cell-scale biophysical determinants of cell competition in epithelia.

ABSTRACT: How cells with different genetic makeups compete in tissues is an outstanding question in developmental biology and cancer research. Studies in recent years have revealed that cell competition can either be driven by short-range biochemical signalling or by long-range mechanical stresses in the tissue. To date, cell competition has generally been characterised at the population scale, leaving the single-cell-level mechanisms of competition elusive. Here, we use high time-resolution experimental data to construct a multi-scale agent-based model for epithelial cell competition and use it to gain a conceptual understanding of the cellular factors that governs competition in cell populations within tissues. We find that a key determinant of mechanical competition is the difference in homeostat

SUBMITTER: Gradeci D 

PROVIDER: S-EPMC8137148 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature