Dataset Information

Single-centre retrospective analysis of the best timing for the QTc interval length assessment in neonates.

ABSTRACT:

Objective

To evaluate the best timing for ECG screening in order to diagnose long QT syndrome and lower, at the same time, the false positives.

Design

We retrospectively evaluated the corrected QT (QTc) interval in the clinical reports of the ECG screening performed, as per internal protocol.

Setting

An outpatient setting in our Unit of Neonatology and Pediatrics, Santa Maria Goretti Hospital in Latina, Italy.

Patients

We enrolled 3467 healthy neonates between 14 and 30 days of life.

Interventions

The newborns with abnormal QTc interval were invited to subsequent revaluation every 21 days, until normalisation or necessity to refer to a tertiary paediatric cardiology centre.

Main outcome measures

Difference in QTc according to patients' characteristics and number of false positives at second ECG evaluation.

Results

At first evaluation, 249 (7.2%) newborns had prolonged QTc. We did not find any significant difference in the QTc length according to gestational age (p=0.40) and birth weight (p=0.81). As expected, girls had longer QTc than boys (p=0.01). Only 11 out of 240 (4.6%) and 1 out of 238 infants (0.4%) had persistently prolonged QTc at second and third ECG evaluation, respectively. The QTc decreased significantly at second (p<0.0001) and third evaluation (p=0.0035).

Conclusions

In our study, we showed that a single screening performed in healthy infants after 60 days of life could reduce the risk of false positives, with a beneficial impact on public national health system and the chance to start early therapy in case of long QT syndrome.

SUBMITTER: Marcellino A

PROVIDER: S-EPMC8137191 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Single-centre retrospective analysis of the best timing for the QTc interval length assessment in neonates.

Marcellino Alessia A Luchetti Jessica J Raponi Massimo M Falsaperla Raffaele R Pirone Carmelo C Fares Maria Katia MK Ventriglia Flavia F Lubrano Riccardo R

BMJ paediatrics open 20210518 1

<h4>Objective</h4>To evaluate the best timing for ECG screening in order to diagnose long QT syndrome and lower, at the same time, the false positives.<h4>Design</h4>We retrospectively evaluated the corrected QT (QTc) interval in the clinical reports of the ECG screening performed, as per internal protocol.<h4>Setting</h4>An outpatient setting in our Unit of Neonatology and Pediatrics, Santa Maria Goretti Hospital in Latina, Italy.<h4>Patients</h4>We enrolled 3467 healthy neonates between 14 and ...[more]

PMID: 34079915

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Dataset Information

Single-centre retrospective analysis of the best timing for the QTc interval length assessment in neonates.

Objective

Design

Setting

Patients

Interventions

Main outcome measures

Results

Conclusions

Publications

Single-centre retrospective analysis of the best timing for the QTc interval length assessment in neonates.

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