Association between absolute lymphocyte count and overall mortality in patients with surgically resected gastric cancer.

ABSTRACT:

Background/aims

Lymphocytes are an important component of the cell-mediated immune system. As lymphopenia is reportedly associated with poor prognoses in patients with various cancers, we investigated this notion in patients who underwent curative gastrectomy.

Methods

We retrospectively analyzed the association between absolute lymphocyte count (ALC) and prognosis in patients with stage I-III gastric cancer who underwent curative surgical resection. Ever lymphopenic patients were defined as those with ALCs < 1,000/μL at any time post-diagnosis except within 30 days post-surgery. Adjusted multivariable regression models were used to evaluate the associations between lymphopenia and overall mortality, gastric cancer-specific mortality, and disease-free survival.

Results

SUBMITTER: Park SJ 

PROVIDER: S-EPMC8137401 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature