Targeting the Mevalonate Pathway in Cancer.
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ABSTRACT:
SUBMITTER: Juarez D
PROVIDER: S-EPMC8137523 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Targeting the Mevalonate Pathway in Cancer.
Juarez Dennis D Fruman David A DA
Trends in cancer 20210106 6
The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol management and cardiovascular health. Thirty years of research have uncovered supportive roles for the mevalonate pathway in numerous cellular processes that support oncogenesis, most recently macropinocytosis. Central to the diverse mechanisms of statin sensitivity is an acquired dependence on one mevalonate pathway output, protein geranylgeranylation. New chemical prenylation probes and the discovery of a n ...[more]
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