In Vivo Printing of Nanoenabled Scaffolds for the Treatment of Skeletal Muscle Injuries.

ABSTRACT: Extremity skeletal muscle injuries result in substantial disability. Current treatments fail to recoup muscle function, but properly designed and implemented tissue engineering and regenerative medicine techniques can overcome this challenge. In this study, a nanoengineered, growth factor-eluting bioink that utilizes Laponite nanoclay for the controlled release of vascular endothelial growth factor (VEGF) and a GelMA hydrogel for a supportive and adhesive scaffold that can be crosslinked in vivo is presented. The bioink is delivered with a partially automated handheld printer for the in vivo formation of an adhesive and 3D scaffold. The effect of the controlled delivery of VEGF alone or paired with adhesive, supportive, and fibrilar architecture has not been studied in volumetric muscle lo

SUBMITTER: Quint JP 

PROVIDER: S-EPMC8137605 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature