Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice.

ABSTRACT:

Purpose

Inulin is a type of fermentable dietary fiber, which is non-digestible, and can improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate the role of inulin in hyperuricemia and microbial composition of the gut microbiota in a mouse model of hyperuricemia established through knockout of Uox (urate oxidase) gene.

Methods

KO (Uox-knockout) and WT (wild-type) mice were given inulin or saline by gavage for 7 weeks. The effect of inulin to combat hyperuricemia was determined by assessing the changes in serum UA (uric acid) levels, inflammatory parameters, epithelial barrier integrity, fecal microbiota alterations, and SCFA (short-chain fatty acid) concentrations in KO mice.

Results

Inulin supplementation can effectively alleviate

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8137640 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature