Association between Smoking History and Tumor Mutation Burden in Advanced Non-Small Cell Lung Cancer.

ABSTRACT: Lung carcinogenesis is a complex and stepwise process involving accumulation of genetic mutations in signaling and oncogenic pathways via interactions with environmental factors and host susceptibility. Tobacco exposure is the leading cause of lung cancer, but its relationship to clinically relevant mutations and the composite tumor mutation burden (TMB) has not been fully elucidated. In this study, we investigated the dose-response relationship in a retrospective observational study of 931 patients treated for advanced-stage non-small cell lung cancer (NSCLC) between April 2013 and February 2020 at the Dana Farber Cancer Institute and Brigham and Women's Hospital. Doubling smoking pack-years was associated with increased KRAS^G12C and less frequent EGFR^del19

SUBMITTER: Wang X 

PROVIDER: S-EPMC8137661 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature