Response to targeted cognitive training may be neuroprotective in patients with early schizophrenia.

ABSTRACT: Individuals with schizophrenia exhibit widespread cortical thinning associated with illness severity and deficits in cognition. However, intact cortical thickness (CTh) may serve as a protective factor. The current study sought to examine changes in CTh in response to auditory targeted cognitive training (TCT) in individuals with recent onset schizophrenia. Participants underwent MRI scanning and a cognitive assessment before and after being randomly assigned to 40 h of either TCT (N = 21) or a computer games control condition (CG; N = 22) over 16 weeks. Groups did not differ at baseline on demographic variables or measures of CTh. At the level of group averages, neither group showed significant pre-post changes in CTh in any brain region. However, changes in CTh related to individual diff

SUBMITTER: Ramsay IS 

PROVIDER: S-EPMC8137670 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature