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Complete genome sequence of Streptomyces cyanogenus S136, producer of anticancer angucycline landomycin A.

ABSTRACT: Streptomyces cyanogenus S136 is the only known producer of landomycin A (LaA), one of the founding members of angucycline family of aromatic polyketides. LaA displays potent anticancer activities which has made this natural product a target of numerous chemical and cell biological studies. Little is known about the potential of S136 strain to produce other secondary metabolites. Here we report complete genome sequence of LaA producer and how we used this sequence to evaluate for this species its phylogenetic position and diversity of gene clusters for natural product biosynthesis.

Supplementary information

The online version contains supplementary material available at 10.1007/s13205-021-02834-4.

SUBMITTER: Hrab P 

PROVIDER: S-EPMC8137763 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Complete genome sequence of <i>Streptomyces cyanogenus</i> S136, producer of anticancer angucycline landomycin A.

Hrab Pavlo P   Rückert Christian C   Busche Tobias T   Ostash Iryna I   Kalinowski Jörn J   Fedorenko Victor V   Yushchuk Oleksandr O   Ostash Bohdan B  

3 Biotech 20210521 6

<i>Streptomyces cyanogenus</i> S136 is the only known producer of landomycin A (LaA), one of the founding members of angucycline family of aromatic polyketides. LaA displays potent anticancer activities which has made this natural product a target of numerous chemical and cell biological studies. Little is known about the potential of S136 strain to produce other secondary metabolites. Here we report complete genome sequence of LaA producer and how we used this sequence to evaluate for this spec  ...[more]

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