Ontology highlight
ABSTRACT:
SUBMITTER: Oyler-Yaniv J
PROVIDER: S-EPMC8137918 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Oyler-Yaniv Jennifer J Oyler-Yaniv Alon A Maltz Evan E Wollman Roy R
Nature communications 20210520 1
Rapid death of infected cells is an important antiviral strategy. However, fast decisions that are based on limited evidence can be erroneous and cause unnecessary cell death and subsequent tissue damage. How cells optimize their death decision making strategy to maximize both speed and accuracy is unclear. Here, we show that exposure to TNF, which is secreted by macrophages during viral infection, causes cells to change their decision strategy from "slow and accurate" to "fast and error-prone". ...[more]