Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2.

ABSTRACT: The EMX (Empty Spiracles Homeobox) genes EMX1 and EMX2 are two homeodomain gene members of the EMX family of transcription factors involved in the regulation of various biological processes, such as cell proliferation, migration, and differentiation, during brain development and neural crest migration. They play a role in the specification of positional identity, the proliferation of neural stem cells, and the differentiation of certain neuronal cell phenotypes. In general, they act as transcription factors in early embryogenesis and neuroembryogenesis from metazoans to higher vertebrates. The EMX1 and EMX2's potential as tumor suppressor genes has been suggested in some cancers. Our work showed that EMX1/EMX2 act as tumor suppressors in sarcomas by repressing the activity of stem cell reg

SUBMITTER: Jimenez-Garcia MP 

PROVIDER: S-EPMC8137939 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature