Opposite alterations of 5-HT_2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile.

ABSTRACT: The status of serotonin 5-HT_2A receptors (5-HT_2ARs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5-HT_2AR density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study investigates 5-HT_2AR density in the post-mortem prefrontal cortex from subjects with schizophrenia and controls using three radiotracers with a different pharmacological profile. The specific binding parameters of the inverse agonist [¹⁸F]altanserin, the agonist [³H]lysergic acid diethylamide (LSD) and the antagonist [³H]MDL100907 to brain cortex m

SUBMITTER: Diez-Alarcia R 

PROVIDER: S-EPMC8137947 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature