Functional and in silico Characterization of Neutralizing Interactions Between Antibodies and the Foot-and-Mouth Disease Virus Immunodominant Antigenic Site.

ABSTRACT: Molecular knowledge of virus-antibody interactions is essential for the development of better vaccines and for a timely assessment of the spread and severity of epidemics. For foot-and-mouth disease virus (FMDV) research, in particular, computational methods for antigen-antibody (Ag-Ab) interaction, and cross-antigenicity characterization and prediction are critical to design engineered vaccines with robust, long-lasting, and wider response against different strains. We integrated existing structural modeling and prediction algorithms to study the surface properties of FMDV Ags and Abs and their interaction. First, we explored four modeling and two Ag-Ab docking methods and implemented a computational pipeline based on a reference Ag-Ab structure for FMDV of serotype C, to be used as a sou

SUBMITTER: Marrero Diaz de Villegas R 

PROVIDER: S-EPMC8137985 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature