Prognostic Value and Related Regulatory Networks of MRPL15 in Non-Small-Cell Lung Cancer.

ABSTRACT:

Background

Mitochondrial ribosomal protein L15 (MRPL15), a member of mitochondrial ribosomal proteins whose abnormal expression is related to tumorigenesis. However, the prognostic value and regulatory mechanisms of MRPL15 in non-small-cell lung cancer (NSCLC) remain unclear.

Methods

GEPIA, ONCOMINE, Gene Expression Omnibus (GEO), UALCAN, Kaplan-Meier plotter, PrognoScan, LinkedOmics and GeneMANIA database were utilized to explore the expression and prognostic value of MRPL15 in NSCLC. Additionally, immune infiltration patterns were evaluated via ESTIMATE algorithm and TISIDB database. Furthermore, the expression and prognostic value of MRPL15 in lung cancer were validated via immunohistochemistry (IHC) assays.

Results

In NSCLC, multiple cohorts includin

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC8138120 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature