Proteomics Landscape of Host-Pathogen Interaction in Acinetobacter baumannii Infected Mouse Lung.

ABSTRACT: Acinetobacter baumannii is an important pathogen of nosocomial infection worldwide, which can primarily cause pneumonia, bloodstream infection, and urinary tract infection. The increasing drug resistance rate of A. baumannii and the slow development of new antibacterial drugs brought great challenges for clinical treatment. Host immunity is crucial to the defense of A. baumannii infection, and understanding the mechanisms of immune response can facilitate the development of new therapeutic strategies. To characterize the system-level changes of host proteome in immune response, we used tandem mass tag (TMT) labeling quantitative proteomics to compare the proteome changes of lungs from A. baumannii infected mice with control mice 6 h after infection. A total of 6

SUBMITTER: Li X 

PROVIDER: S-EPMC8138179 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature