Modulation of premotor cortex response to sequence motor learning during escitalopram intake.

ABSTRACT: The contribution of selective serotonin reuptake inhibitors to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we use functional magnetic resonance imaging in a double-blind, randomized controlled study to assess whether 20 mg escitalopram improves sequence-specific motor performance and modulates cortical motor response in 64 healthy female participants. We found decreased left premotor cortex responses during sequence-specific learning performance comparing single dose and steady escitalopram state. Escitalopram plasma levels negatively correlated with the premotor cortex response. We did not find evidence in

SUBMITTER: Molloy EN 

PROVIDER: S-EPMC8138331 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature