Heterogeneity of Pulmonary Granulomas in Cattle Experimentally Infected With Mycobacterium bovis.

ABSTRACT: Mycobacterium bovis is the cause of tuberculosis in most animals, most notably cattle. The stereotypical lesion of bovine tuberculosis is the granuloma; a distinct morphological lesion where host and pathogen interact and disease outcome (i.e., dissemination, confinement, or resolution) is determined. Accordingly, it is critical to understand host-pathogen interactions at the granuloma level. Host-pathogen interactions within individual granulomas at different stages of disease have not been examined in cattle. We examined bacterial burden and cytokine expression in individual pulmonary granulomas from steers at 30, 90, 180, and 270 days after experimental aerosol infection with M. bovis. Bacterial burdens within individual granulomas examined 30 days after infection were gre

SUBMITTER: Palmer MV 

PROVIDER: S-EPMC8138452 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature