Novel Cephalosporins in Septic Subjects and Severe Infections: Present Findings and Future Perspective.

ABSTRACT: In past decade, cephalosporins have developed significantly, and data regarding novel cephalosporins (i.e., ceftobiprole, ceftaroline, ceftolozane/tazobactam, ceftazidime/avibactam, and cefiderocol) within septic and bacteremic subjects are rising. These compounds generally offer very promising in vitro microbiological susceptibility, although the variability among gram-negative and -positive strains of different cohorts is noticed in the literature. We require further pharmacological data to measure the best dose in order to prevent sub-therapeutic drug levels in critically ill patients. These new compounds in theory are the sparing solution in the Enterobacteriales infection group for different antimicrobial classes such as aminoglycosides notably within endovascular and GN

SUBMITTER: Corcione S 

PROVIDER: S-EPMC8138473 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature