Drug Repurposing: In vitro and in vivo Antimicrobial and Antibiofilm Effects of Bithionol Against Enterococcus faecalis and Enterococcus faecium.
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SUBMITTER: She P
PROVIDER: S-EPMC8138570 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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Drug Repurposing: <i>In vitro</i> and <i>in vivo</i> Antimicrobial and Antibiofilm Effects of Bithionol Against <i>Enterococcus faecalis</i> and <i>Enterococcus faecium</i>.
She Pengfei P Wang Yangxia Y Li Yingjia Y Zhou Linying L Li Shijia S Zeng Xianghai X Liu Yaqian Y Xu Lanlan L Wu Yong Y
Frontiers in microbiology 20210506
Widespread antibiotic resistance has been reported in enterococcal pathogens that cause life-threatening infections. Enterococci species rapidly acquire resistance and the pace of new antibiotic development is slow. Drug repurposing is a promising approach in solving this problem. Bithionol (BT) is a clinically approved anthelminthic drug. In this study, we found that BT showed significant antimicrobial and antibiofilm effects against <i>Enterococcus faecalis</i> and vancomycin-resistant <i>Ente ...[more]
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