Evidence for Chloroquine/Hydroxychloroquine in the Treatment of COVID-19.

ABSTRACT:

Introduction

Given the current lack of an approved and effective treatment or vaccine for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), repositioning old drugs for use as an antiviral treatment is an interesting strategy because knowledge about these drugs' safety profile, posology, and drug interactions is already known. Chloroquine and hydroxychloroquine, widely used as antimalarial and autoimmune disease drugs, have recently been reported as a potential broad-spectrum antiviral drug.

Background

The in vitro antiviral activity of chloroquine has been identified since the late 1960s. However, antiviral mechanisms of chloroquine remain speculative. Several clinical trials have been conducted to test the efficacy and safety of chloroquine or hydroxychlo

SUBMITTER: Shetty RM 

PROVIDER: S-EPMC8138637 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature