Maternal Substance Abuse and the Later Risk of Fractures in Offspring: L'abus maternel de substances et le risque ulterieur de fractures chez les enfants.

ABSTRACT:

Objective

To assess the association of maternal illicit drug abuse before or during pregnancy with future fractures in offspring.

Methods

We performed a longitudinal cohort study of 792,022 infants born in hospitals of Quebec, Canada, between 2006 and 2016, with 5,457,634 person-years of follow-up. The main exposure was maternal substance abuse before or during pregnancy, including cocaine, opioid, cannabis, and other illicit drugs. The main outcome measure was hospitalization for traumatic fracture in offspring up to 12 years of age. We used adjusted Cox regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association of maternal drug abuse with the subsequent risk of fracture in children.

Results

The incidence of child fractures

SUBMITTER: Auger N 

PROVIDER: S-EPMC8138743 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature