Association of Structural Changes in the Brain and Retina After Long-Duration Spaceflight.

ABSTRACT:

Importance

Long-duration spaceflight induces structural changes in the brain and eye. Identification of an association between cerebral and ocular changes could help determine if there are common or independent causes and inform targeted prevention strategies or treatments.

Objective

To determine if there is an association between quantitative changes in intracranial compartment volumes and peripapillary total retinal thickness after spaceflight.

Design, setting, and participants

This cohort study included healthy International Space Station crew members before and immediately after long-duration spaceflight. Data on race were not collected. Analysis was conducted from September to November 2020.

Exposures

Long-duration spaceflight (mean [SD], 191 [55] days).

SUBMITTER: Marshall-Goebel K 

PROVIDER: S-EPMC8138750 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature