Enlargement of Geographic Atrophy From First Diagnosis to End of Life.

ABSTRACT:

Importance

Treatments for geographic atrophy (GA), a late stage of age-related macular degeneration (AMD), are currently under development. Understanding the natural course is needed for optimal trial design. Although enlargement rates of GA and visual acuity (VA) in the short term are known from clinical studies, knowledge of enlargement in the long term, life expectancy, and visual course is lacking.

Objective

To determine long-term enlargement of GA.

Design, setting, and participants

In this study, participant data were collected from 4 population-based cohort studies, with up to 25 years of follow-up and eye examinations at 5-year intervals: the Rotterdam Study cohorts 1, 2, and 3 and the Blue Mountains Eye Study. Data were collected from 1990 to 2015, and data we

SUBMITTER: Colijn JM 

PROVIDER: S-EPMC8138753 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature