Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.

ABSTRACT: Using a variety of activating and inhibitory receptors, natural killer (NK) cells protect against disease by eliminating cells that have downregulated class I major histocompatibility complex (MHC) proteins, such as in response to cell transformation or viral infection. The inhibitory murine NK receptor Ly49C specifically recognizes the class I MHC protein H-2K^b. Unusual among NK receptors, Ly49C exhibits a peptide-dependent sensitivity to H-2K^b recognition, which has not been explained despite detailed structural studies. To gain further insight into Ly49C peptide sensitivity, we examined Ly49C recognition biochemically and through the lens of dynamic allostery. We found that the peptide sensitivity of Ly49C arises through small differences in H-2K^b-bindin

SUBMITTER: Ma J 

PROVIDER: S-EPMC8138769 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature