Deep4mC: systematic assessment and computational prediction for DNA N4-methylcytosine sites by deep learning.

ABSTRACT: DNA N4-methylcytosine (4mC) modification represents a novel epigenetic regulation. It involves in various cellular processes, including DNA replication, cell cycle and gene expression, among others. In addition to experimental identification of 4mC sites, in silico prediction of 4mC sites in the genome has emerged as an alternative and promising approach. In this study, we first reviewed the current progress in the computational prediction of 4mC sites and systematically evaluated the predictive capacity of eight conventional machine learning algorithms as well as 12 feature types commonly used in previous studies in six species. Using a representative benchmark dataset, we investigated the contribution of feature selection and stacking approach to the model construction, and found that fe

SUBMITTER: Xu H 

PROVIDER: S-EPMC8138820 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature