Joint reconstruction of cis-regulatory interaction networks across multiple tissues using single-cell chromatin accessibility data.

ABSTRACT: The rapid accumulation of single-cell chromatin accessibility data offers a unique opportunity to investigate common and specific regulatory mechanisms across different cell types. However, existing methods for cis-regulatory network reconstruction using single-cell chromatin accessibility data were only designed for cells belonging to one cell type, and resulting networks may be incomparable directly due to diverse cell numbers of different cell types. Here, we adopt a computational method to jointly reconstruct cis-regulatory interaction maps (JRIM) of multiple cell populations based on patterns of co-accessibility in single-cell data. We applied JRIM to explore common and specific regulatory interactions across multiple tissues from single-cell ATAC-seq dataset containing ~80 000 cells

SUBMITTER: Dong K 

PROVIDER: S-EPMC8138825 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature