MiRactDB characterizes miRNA-gene relation switch between normal and cancer tissues across pan-cancer.

ABSTRACT: It has been increasingly accepted that microRNA (miRNA) can both activate and suppress gene expression, directly or indirectly, under particular circumstances. Yet, a systematic study on the switch in their interaction pattern between activation and suppression and between normal and cancer conditions based on multi-omics evidences is not available. We built miRactDB, a database for miRNA-gene interaction, at https://ccsm.uth.edu/miRactDB, to provide a versatile resource and platform for annotation and interpretation of miRNA-gene relations. We conducted a comprehensive investigation on miRNA-gene interactions and their biological implications across tissue types in both tumour and normal conditions, based on TCGA, CCLE and GTEx databases. We particularly explored the genetic and epigeneti

SUBMITTER: Tan H 

PROVIDER: S-EPMC8138827 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature