MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations.

ABSTRACT:

Background

Multi-region sequencing (MRS) has been widely used to analyze intra-tumor heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational data from MRS is still challenging, necessitating complicated integration of a plethora of computational and statistical approaches.

Findings

Here, we present MesKit, an R/Bioconductor package that can assist in characterizing genetic ITH and tracing the evolutionary history of tumors based on somatic alterations detected by MRS. MesKit provides a wide range of analysis and visualization modules, including ITH evaluation, metastatic route inference, and mutational signature identification. In addition, MesKit implements an auto-layout algorithm to generate phylogenetic trees based on somatic mutations. Th

SUBMITTER: Liu M 

PROVIDER: S-EPMC8138830 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature