Recent advances in user-friendly computational tools to engineer protein function.

ABSTRACT: Progress in technology and algorithms throughout the past decade has transformed the field of protein design and engineering. Computational approaches have become well-engrained in the processes of tailoring proteins for various biotechnological applications. Many tools and methods are developed and upgraded each year to satisfy the increasing demands and challenges of protein engineering. To help protein engineers and bioinformaticians navigate this emerging wave of dedicated software, we have critically evaluated recent additions to the toolbox regarding their application for semi-rational and rational protein engineering. These newly developed tools identify and prioritize hotspots and analyze the effects of mutations for a variety of properties, comprising ligand binding, protein-prote

SUBMITTER: Sequeiros-Borja CE 

PROVIDER: S-EPMC8138880 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature