Gut microbiome variation modulates the effects of dietary fiber on host metabolism.

ABSTRACT:

Background

There is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and by increasing production of beneficial metabolites in the distal gut. However, human studies have reported variations in the observed benefits among individuals consuming the same fiber. Several factors likely contribute to this variation, including host genetic and gut microbial differences. We hypothesized that gut microbial metabolism of dietary fiber represents an important and differential factor that modulates how dietary fiber impacts the host.

Results

We examined genetically identical gnotobiotic mice harboring two distinct complex gut microbial communities and exposed to four isocaloric diets, each contain

SUBMITTER: Murga-Garrido SM 

PROVIDER: S-EPMC8138933 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature