Neuron-specific cilia loss differentially alters locomotor responses to amphetamine in mice.

ABSTRACT: The neural mechanisms that underlie responses to drugs of abuse are complex, and impacted by a number of neuromodulatory peptides. Within the past 10 years it has been discovered that several of the receptors for neuromodulators are enriched in the primary cilia of neurons. Primary cilia are microtubule-based organelles that project from the surface of nearly all mammalian cells, including neurons. Despite what we know about cilia, our understanding of how cilia regulate neuronal function and behavior is still limited. The primary objective of this study was to investigate the contributions of primary cilia on specific neuronal populations to behavioral responses to amphetamine. To test the consequences of cilia loss on amphetamine-induced locomotor activity we selectively ablated cilia fr

SUBMITTER: Ramos C 

PROVIDER: S-EPMC8138950 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature