Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study.

ABSTRACT:

Background

Melatonin is a hormone that is secreted at night by the pineal gland. It exerts its function by binding to the MT₁ and MT₂ receptors, which are encoded by the MTNR1A and MTNR1B genes, respectively. Previous studies reveal that MTNR1B variants are associated with insulin secretion impairments and an increased body mass index (BMI) in individuals of European and Asian ancestries. Obesity is highly prevalent in the US and disproportionately affects African Americans. Here, we hypothesized that common single nucleotide polymorphisms (SNPs) imputed in 1000 Genomes in the MTNR1B gene are associated with adiposity in African American adult men and women and that the association is modified by insomnia.

Methods

We used an additive genetic model to de

SUBMITTER: Tchio C 

PROVIDER: S-EPMC8138980 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature