Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia.

ABSTRACT:

Objective

Proinflammatory cytokine interleukin 17 (IL-17) is involved in ventricular remodeling, mainly of the left ventricle. This study was designed to explore the role of IL-17 played in the pathogenesis of right ventricular hypertrophy (RVH), aiming to provide a novel treatment target or diagnostic biomarker options for improving the care of RVH patients.

Methods

C57BL/6 mice were maintained in 10% O₂ chamber or room air for four weeks. Right ventricular hypertrophy index (RVHI), RV/body weight ratio, pulmonary arteriolar remodeling determined by percent media thickness (%MT), and the cardiomyocyte diameter of RV were evaluated. Mice were treated with exogenous recombinant mouse IL-17 (rmIL-17, 1 μg per dose twice a week) for four weeks. H9c2 cardiomyocytes we

SUBMITTER: Huang J 

PROVIDER: S-EPMC8139008 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature