A cyclic nano-reactor achieving enhanced photodynamic tumor therapy by reversing multiple resistances.

ABSTRACT:

Background

Photodynamic therapy (PDT) is a clinically implemented modality to combat malignant tumor, while its efficacy is largely limited by several resistance factors from tumor microenvironment (TME), such as hypoxia, anti-oxidant systems, and ATP-dependent tumor adaptive resistances. The aim of this work is to construct a multifunctional nanoplatform to remodel multiple resistant TME for enhanced PDT.

Results

Here, a targeting nano-reactor was facilely constructed to reverse the multiple resistances of PDT by incorporating glucose oxidase (GOx) and chlorin e6 (Ce6) into poly (D, L-lactic-co-glycolic acid) (PLGA)/ metal-organic framework (MOF) core-shell nanoassembly, with surface deposition of hyaluronic acid (HA) stabilized MnO₂. The nano-reactor could selec

SUBMITTER: Liu P 

PROVIDER: S-EPMC8139056 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature