Replication of GWAS significant loci in a sub-Saharan African Cohort with early childhood caries: a pilot study.

ABSTRACT:

Background

Early childhood caries (ECC) is a rapidly progressing form of dental infection and a significant public health problem, especially among socially and economically disadvantaged populations. This study aimed to assess the risk factors for ECC among a cohort of Sub-Saharan African children and to determine the role of genetics in the etiology of ECC.

Methods

A sample of 691 children (338 with ECC, 353 without ECC, age < 6 years) was recruited from schools in Lagos, Nigeria. Socio-demographic, dental services utilization and infant dietary data were obtained with interviewer-administered questionnaire. Oral examination was conducted using the WHO oral health diagnostic criteria. Saliva samples were collected from the children for genetic analysis. Single nucleotide p

SUBMITTER: Olatosi OO 

PROVIDER: S-EPMC8139096 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature