Examination of gender differences in patients with takotsubo syndrome according to left ventricular biopsy: two case reports.

ABSTRACT:

Background

Takotsubo syndrome is a stress-induced disease that makes up 2-3% of acute coronary syndrome cases. However, its onset mechanism remains unclear. Although females are overwhelmingly affected, males end up having more cardiac complications.

Case presentation

We examined the differences in stress responses in the myocardium between sexes in patients with takotsubo syndrome. We biopsied samples from an over 70-year-old Japanese male and an over 80-year-old Japanese female. Tissues from the left ventricle apex in the acute phase and the apical ballooning-type were examined using histopathology and deoxyribonucleic acid (DNA) microarray analysis. Our data showed that left ventricular ejection fractions were 38% and 56%, and peak creatinine kinase concentrations during

SUBMITTER: Murakami T 

PROVIDER: S-EPMC8139097 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature