Association of arterial stiffness with incident atrial fibrillation: a cohort study.

ABSTRACT:

Background

Stiff arteries increase left ventricular (LV) end-systolic workload, leading over time to left atrial and ventricular remodeling, and providing the substrate for atrial fibrillation (AF) development. We investigated if carotid femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness, is associated with incident AF.

Methods

In 2011-2013, cfPWV was measured in 3882 participants of the Atherosclerosis Risk in Communities Cohort Study (ARIC) without prevalent AF. Participants were followed through 2017 for the incidence of AF. Individuals were categorized in cfPWV quartiles based on visit measurements. Multivariable Cox regression models were used to evaluate the association of cfPWV with incident AF.

Results

Mean age was 75 years (SD 5), 60

SUBMITTER: Almuwaqqat Z 

PROVIDER: S-EPMC8139144 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature