Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans.

ABSTRACT:

Background

The majority of the human genome is transcribed in the form of long non-coding (lnc) RNAs. While these transcripts have attracted considerable interest, their molecular mechanisms of function and biological significance remain controversial. One of the main reasons behind this lies in the significant challenges posed by lncRNAs requiring the development of novel methods and concepts to unravel their functionality. Existing methods often lack cross-validation and independent confirmation by different methodologies and therefore leave significant ambiguity as to the authenticity of the outcomes. Nonetheless, despite all the caveats, it appears that lncRNAs may function, at least in part, by regulating other genes via chromatin interactions. Therefore, the function of a lnc

SUBMITTER: Cao H 

PROVIDER: S-EPMC8139166 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature