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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19.

ABSTRACT: Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.

SUBMITTER: Grifoni A

PROVIDER: S-EPMC8139264 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19.

Grifoni Alba A Sidney John J Vita Randi R Peters Bjoern B Crotty Shane S Weiskopf Daniela D Sette Alessandro A

Cell host & microbe 20210521 7

Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes ...[more]

PMID: 34237248

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