Adult neural stem cells have latent inflammatory potential that is kept suppressed by <i>Tcf4</i> to facilitate adult neurogenesis.

ABSTRACT: Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (Tcf4). Deletion of Tcf4 in hippocampal nestin-expressing progenitors causes loss of proliferative capacity and acquisition of myeloid inflammatory properties. This transformation abolishes their differentiation potential and causes production of detrimental factors that adversely affect niche cells, causing inflammation in the dentate gyrus. Thus, on one hand, Tcf4 deletion causes abrogation of proliferative progenitors leading to reduction of adult ne

SUBMITTER: Shariq M 

PROVIDER: S-EPMC8139598 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature