Engineered influenza virions reveal the contributions of non-hemagglutinin structural proteins to vaccine mediated protection.

ABSTRACT: The development of improved and universal anti-influenza vaccines would represent a major advance in the protection of human health. In order to facilitate the development of such vaccines, understanding how viral proteins can contribute to protection from disease is critical. Much of the previous work to address these questions relied on reductionist systems (i.e. vaccinating with individual proteins or VLPs that contain only a few viral proteins); thus we have an incomplete understanding of how immunity to different subsets of viral proteins contribute to protection. Here, we report the development of a platform in which a single viral protein can be deleted from an authentic viral particle that retains the remaining full complement of structural proteins and viral RNA. As a first study

SUBMITTER: Luo Z 

PROVIDER: S-EPMC8139674 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature