Dataset Information

Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study.

ABSTRACT:

Aims

Present society is constantly ageing and elderly frequently suffer from conditions that are difficult and/or costly to treat if detected late. Effective screening of the elderly is therefore needed so that those requiring detailed clinical work-up are identified early. We present a prospective validation of a screening strategy based on a Polyscore of seven predominantly autonomic, non-invasive risk markers.

Methods and results

Within a population-based survey in Germany (INVADE study), participants aged ≥60 years were enrolled between August 2013 and February 2015. Seven prospectively defined Polyscore components were obtained during 30-min continuous recordings of electrocardiogram, blood pressure, and respiration. Out of 1956 subjects, 168 were excluded due to atrial fibrillation, implanted pacemaker, or unsuitable recordings. All-cause mortality over a median 4-year follow-up was prospectively defined as the primary endpoint. The Polyscore divided the investigated population (n = 1788, median age: 72 years, females: 58%) into three predefined groups with low (n = 1405, 78.6%), intermediate (n = 326, 18.2%), and high risk (n = 57, 3.2%). During the follow-up, 82 (4.6%) participants died. Mortality in the Polyscore-defined risk groups was 3.4%, 7.4%, and 17.5%, respectively (P < 0.0001). The Polyscore-based mortality prediction was independent of Framingham score, diabetes, chronic kidney disease, and major stroke and/or myocardial infarction history. It was particularly effective in those aged <75 years (n = 1145).

Conclusion

The Polyscore-based mortality risk assessment from short-term non-invasive recordings is effective in the elderly general population, especially those aged 60-74 years. Implementation of a comprehensive Polyscore screening of this age group is proposed to advance preventive medical care.

SUBMITTER: Steger A

PROVIDER: S-EPMC8139819 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study.

Steger Alexander A Dommasch Michael M Müller Alexander A Sinnecker Daniel D Huster Katharina M KM Gotzler Teresa T Gotzler Othmar O Hapfelmeier Alexander A Ulm Kurt K Barthel Petra P Hnatkova Katerina K Laugwitz Karl-Ludwig KL Malik Marek M Malik Marek M Schmidt Georg G

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20210501 5

<h4>Aims</h4>Present society is constantly ageing and elderly frequently suffer from conditions that are difficult and/or costly to treat if detected late. Effective screening of the elderly is therefore needed so that those requiring detailed clinical work-up are identified early. We present a prospective validation of a screening strategy based on a Polyscore of seven predominantly autonomic, non-invasive risk markers.<h4>Methods and results</h4>Within a population-based survey in Germany (INV ...[more]

PMID: 33276379

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Dataset Information

Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study.

Aims

Methods and results

Conclusion

Publications

Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study.

Similar Datasets

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