Comprehensive genomic and immunophenotypic analysis of CD4 T cell infiltrating human triple-negative breast cancer.

ABSTRACT: The aim of this study is to investigate the gene expression module of tumor-infiltrating CD4⁺T cells and its potential roles in modulating immune cell functions in triple-negative breast cancer. Differentially expressed genes were identified by comparison of the expression profile in CD4⁺T cells isolated from tumor tissues and peripheral blood of TNBC patients respectively. The differential expression analysis was conducted using R, and then the functional and pathway enrichment of the DEGs were analyzed using GSEA, followed by integrated regulatory network construction and genetic analysis of tumor-infiltrating immune cells based on a scientific deconvolution algorithm. As a result, abundant Treg and exhausted lymphocytes were detected, accompanied by largely decreas

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8139937 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature