Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians' Health Study.

ABSTRACT:

Background

Chronic inflammation may lead to frailty, however the potential for anti-inflammatory medications such as aspirin to prevent frailty is unknown. We sought to examine the association between long-term aspirin use and prevalent frailty.

Methods

We included 12 101 men ≥60 years who participated in the Physicians' Health Study I, a completed aspirin randomized controlled trial (1982-1989). Annual questionnaires collected self-reported data on daily aspirin use, lifestyle, and clinical variables. Average aspirin use was summed into 2 categories: ≤60 days/year and >60 days/year. Frailty was assessed using a 33-item index 11 years after trial completion. A score of ≥0.21 was considered frail. Propensity score inverse probability of treatment weighting was used for statis

SUBMITTER: Orkaby AR 

PROVIDER: S-EPMC8140052 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature